Fitness Modeling & Mutation Prediction MCPs

Predict protein fitness landscapes and mutation effects using evolutionary and deep learning approaches.

MCP	Runtime	Description
ESM MCP	docker	ESM for protein embedding and fitness modeling
EV+OneHot MCP	docker	Protein fitness prediction (evolutionary coupling + one-hot encoding)
MutCompute MCP	python	MutCompute for protein mutation effect prediction
PLMC MCP	docker	Evolutionary coupling analysis using PLMC
ProtTrans MCP	docker	ProtTrans for protein embeddings and fitness modeling

Install

Docker MCPs (local build recommended):

cd tool-mcps/esm_mcp && docker build -t esm_mcp:latest . && cd ../..
cd tool-mcps/ev_onehot_mcp && docker build -t ev_onehot_mcp:latest . && cd ../..
cd tool-mcps/plmc_mcp && docker build -t plmc_mcp:latest . && cd ../..
cd tool-mcps/prottrans_mcp && docker build -t prottrans_mcp:latest . && cd ../..

pmcp install esm_mcp
pmcp install ev_onehot_mcp
pmcp install plmc_mcp
pmcp install prottrans_mcp

Python MCP:

pmcp install mutcompute_mcp